<p style="text-align: justify;">MON89034 X MON88017 (OECD identifier: MON-89&Oslash;34-3 X MON-88&Oslash;17-3) maize is an F1 hybrid resulting from the hybridization of maize inbred MON89034 (MON-89&Oslash;34-3) with MON88017 (MON-88&Oslash;17-3). This stacked maize hybrid is a product of traditional plant breeding, and therefore is not automatically subject to regulation in all jurisdictions as are transgenic plants resulting from recombinant DNA technologies. Certain jurisdictions may request notification in advance of the release of a stacked hybrid, or may request information to conduct an environmental and food safety assessment. Examples of jurisdictions that require either notification or information about stacked hybrids prior to their release into the environment, and for use in human food and livestock feed are Canada and Japan.</p>

<p style="text-align: justify;">The stacked hybrid MON89034 X MON88017 expresses three novel insecticidal proteins and a protein providing tolerance to the herbicide glyphosate. MON 89034 produces the Cry1A.105 and Cry2Ab2 proteins, which are active against lepidopteran insect pests and MON88017 produces Cry3Bb1 which confers resistance to Corn Rootworm. All of these proteins are derived from <i>Bacillus thuringiensis</i>. Tolerance to glyphosate is provided by the CP4 EPSPS protein, produced by the <i>cp4 epsps</i> gene from MON88017. The novel traits of each parent line have been combined, through traditional plant breeding, to produce this new hybrid. For a full description of each parent line please refer to the individual product descriptions in the crop database for MON89034 and MON88017.</p>

<p style="text-align: justify;">The inserted genes and their gene products have a history of safe use, and have undergone review and approval by several regulatory agencies. No interactions among the gene products or negative synergistic effects are expected in the stacked hybrid. The Cry1A.105, Cry2Ab2 and Cry3Bb1 proteins are not enzymes and therefore do not affect plant metabolism. The CP4 EPSPS has high affinity for its substrates phosphoenolpyruvate (PEP) and shikimate-3-phosphate, which are part of the shikimate metabolic pathway. These proteins are therefore not expected to interact within, nor affect the metabolism of the stacked hybrid.</p>
