<p style="text-align: justify;"><b>Dietary Exposure:</b></p>

<p style="text-align: justify;">AP602CL Clearfield wheat is expected to be used in similar applications as other wheat varieties. There were no expected changes in gluten content in this variety, thus presenting no new or additional concern for individuals with celiac disease.</p>

<p style="text-align: justify;"><b>Nutritional Analysis:</b></p>

<p style="text-align: justify;">Analysis for nutritional and anti-nutritional components of grain derived from AP602CL Clearfield wheat revealed no significant difference from grain derived from the parent line Gunner wheat. AP602CL had slightly lower fat content, lower oleic acid content and higher threonine content than Gunner, but these differences were determined to have no impact on livestock nutrition. There were no other substantial differences between AP602CL and Gunner in terms of nutritional composition.</p>

<p style="text-align: justify;"><b>Toxicity and Allergenicity:</b></p>

<p style="text-align: justify;">The expression of the modified AHAS enzyme is not associated with any toxicity or allergenicity concerns. AHAS is expressed at very low amounts in the edible portion of wheat, its activity is heat-labile and degrades in the human gastrointestinal tract. The modified AHAS enzyme is not homologous to known allergens and is not different from the unmodified AHAS in its similarity to known allergens. AP602CL wheat does not express any other new proteins or altered amounts of other proteins, including known wheat allergens. It is also unlikely that AP602CL has unintended secondary mutagens that may cause effects on livestock or bystanders.</p>
