<p><span style="color: rgb(89, 89, 89); font-family: Verdana, Helvetica, Arial, 'Sans Serif'; font-size: 11px; line-height: 14px; text-align: justify;">For new varieties without purposefully altered nutritional properties, such as 4114 maize, the compositional assessment is part of the weight-of-evidence approach for evaluating whether there were any unanticipated consequences of the genetic modification.&nbsp;</span><br style="color: rgb(89, 89, 89); font-family: Verdana, Helvetica, Arial, 'Sans Serif'; font-size: 11px; line-height: 14px; text-align: justify;" /><br><span style="color: rgb(89, 89, 89); font-family: Verdana, Helvetica, Arial, 'Sans Serif'; font-size: 11px; line-height: 14px; text-align: justify;">Compositional analyses were performed on samples of maize forage and kernels (grain) obtained from hybrid plants of 4114 and near-isogenic control maize grown in side-by-side trials across six locations in the United States and Canada in 2010. The near-isogenic control plants had a genetic background that was&nbsp;</span><i style="color: rgb(89, 89, 89); font-family: Verdana, Helvetica, Arial, 'Sans Serif'; font-size: 11px; line-height: 14px; text-align: justify;">ca</i><span style="color: rgb(89, 89, 89); font-family: Verdana, Helvetica, Arial, 'Sans Serif'; font-size: 11px; line-height: 14px; text-align: justify;">. 98 percent similar to that of the 4114 maize generation used, but did not go through the transformation process.&nbsp;</span><br><span style="color: rgb(89, 89, 89); font-family: Verdana, Helvetica, Arial, 'Sans Serif'; font-size: 11px; line-height: 14px; text-align: justify;">Among the 82 compositional components that were analyzed in samples of 4114 and near-isogenic control maize grain, and nine components that were analyzed in forage samples, the only statistically significant differences observed were in concentrations of ash, phosphorus, potassium, and eicosenoic acid in grain samples. This number of statistically significant differences is within the range that would be expected purely by chance. The magnitudes of the differences in mean concentrations were small, less than 15 percent, and in every case the mean values from 4114 maize grain samples were within the ranges of natural variation as reported in the literature. Overall, no consistent patterns emerged to suggest that biologically meaningful changes in composition or nutritive value of the grain had occurred as a consequence of the genetic modification, or expression of the Cry1F, Cry34Ab1, Cry35Ab1, and PAT proteins in 4114 maize.</span><br><span style="color: rgb(89, 89, 89); font-family: Verdana, Helvetica, Arial, 'Sans Serif'; font-size: 11px; line-height: 14px; text-align: justify;">The conclusion based on these data was that grain and forage from 4114 maize were compositionally equivalent to these same products from unmodified near-isogenic control maize, and to other commercial maize hybrids. Processing is unlikely to alter the compositional components of maize grain, thus, products derived from 4114 grain will also be compositionally equivalent to their conventional counterparts.</span></p><br>