The regulatory structures underlying United States and European Union policies regarding genetically modified (GM) food and crops are fundamentally different.  The US regulates GM foods and crops as end products, applying roughly the same regulatory framework that it does to non GM foods or crops.  The EU, on the other hand, regulates products of agricultural biotechnology as the result of a specific production process.  Accordingly, it has developed a network of rules that regulate GM foods and crops specifically.  As a result, US regulation of GM foods and crops is relatively permissive, whereas EU regulation is relatively restrictive.  Why are genetically modified food policies in the United States and the European Union so strikingly different? In the light of the recent World Trade Organization dispute on agricultural biotechnology, it may seem that economic interests are the driving force behind policies.  While they are certainly part of the picture, the issue is far more complex.  This paper argues that three different elements help explain differences between US and EU GM food policies.  First, an investigation of US and European policies of the 1970s and 1980s on recombinant DNA research and of events leading up to early GM food and crop regulation allows a deeper understanding of current policy.  Second, scrutinizing underlying values and norms can uncover the beliefs that condition current GM food and crop policy.  Third, an analysis of involved actors' views and levels of success in influencing policy is essential to understanding US and EU policies.