Quality seeds are central to increased agricultural productivity. Thus delivery of such seeds is critical in ensuring that farmers have the best planting materials for optimal productivity. In Kenya, the seed sector consists of informal and formal components. The informal system supplies about 70% of seed to smallholder farmers. These seeds include open pollinated crops such as maize, and self-pollinated varieties like beans. These seeds are typically derived from selected grains at harvest and re-used for planting from season to season. On the other hand, the formal seed system handles high performance seeds such as hybrids and synthetics, which are not amenable to recycling. The formal seed sector is poised to grow considering the sustained investment by the government of Kenya and the private sector in research and development, including biotechnology. These efforts have contributed to emerging transgenic products such as bt-maize and bt-cotton. However, biotechnology products, being new, highly regulated, and often raising safety and ethical concerns will require additional capacities in terms of human, institutional and legal support to create an enabling environment for their acceptance and consumption. This calls for the need for sustainable and responsible use of the emerging biotechnology products along the seed value chain. This paper discusses the experience in handling conventional and transgenic seeds in Kenya, emphasizing lessons for a model pathway that could be adapted for delivery of transgenic crops in other African countries.