Three years of on-farm comparison of Bollgard cotton have been conducted in several U.S. cotton production regions. These comparisons involved 5-10 acre plots of Bollgard compared to a grower selected standard. Bollgard varieties examined included NuCotn 33B, NuCotn 35B, and limited locations comparing newer Delta Pine and Paymaster Bollgard varieties.In Mississippi, Bollgard out-yielded non-Bollgard cotton varieties examined by 92, 46, and 84 lbs. lint per acre on average in 1995, 1996, and 1997, respectively. After yields values and net returns were evaluated, Bollgard demonstrated a cost advantage of $82.50, $24.71, and $53.73 greater than in the non-Bollgard cotton in 1995, 1996, and 1997, respectively. Bollgard net return 3 year average for MS was $53.76 greater than for non-Bollgard.Summaries of comparisons averaged over the 3 year period from 1995 through 1997 (1996 through 1997 for East Texas) demonstrate Bollgard yield advantages of 114, 45, and 54 lbs. lint per acre on average for the Southeast, Delta, and East Texas regions, respectively. Higher net returns also occurred in Bollgard cotton resulting in Bollgard advantages ranging from approximately $11 to $54 depending on the region evaluated.