We use a regulatory model with resistance evolution in two pests to insecticidal Bt cotton and pyrethroids (a conventional insecticide) to examine non-Bt cotton (refuge) planting requirements designed to manage Bt-resistance evolution in the midsouth. Our analysis suggests that reduced refuge requirements would enhance producer profitability, sprayed refugia are more cost effective than unsprayed refugia, and producers would receive slightly higher returns under dynamic relative to static refuge policies. Pyrethroid susceptibility in one of the pests was a renewable resource, and toxin-mixture effects associated with pyrethroid use in Bt cotton were important considerations for midsouth refuge policies.