The United States Environmental Protection Agency (EPA) and the United States Department of Agriculture (USDA) have co-authored this position paper to provide all stakeholders with a central focal point for discussion of insect resistance management (IRM) for toxin genes from Bacillus thuringiensis (Bt) that have been genetically engineered into crop plants (Bt crops). The following five areas will be discussed in more detail: 1) best management principles for IRM for Bt crops, 2) current IRM strategies for 1999, 3) IRM recommendations and implementation for the future, 4) development of regional pest management centers in the future, and 5) workshops on IRM for Bt crops.