Biotechnology-derived (GM) crops have been in commercial use for 10 years with much success in the areas where they have been approved. Prior to intentional (commercial) release, every product underwent an extensive risk assessment examining the potential risks associated with food and feed use and exposure to the environment. However, data collection does not stop once a GM crop is approved for commercial use. Post-market monitoring (PMM) is the collection of information on a specific GM crop in the 'real world'. PMM serves many useful purposes including confirming the findings of the risk assessment and collecting information obtained under commercial use. It also allows companies to gather information useful in helping farmers use a product appropriately. In addition, PMM can help risk assessors and scientists learn about and promote environmentally improved farming practices, and thereby achieve environmental management goals. The aim of this talk is to share a perspective on the benefits and challenges associated with PMM based on experience gained over 10 years with commercial GM crops.