Because host-plant chemistry is dynamic, chemical defenses are dynamic, and senescence in plants causes many proteins to decompose after flowering, laboratory and field studies on transgenic crops performed over only part of a plant generation or part of a season may not provide sufficient data to evaluate strategies for resistance management.  As an example, we focused on the recent introduction of transgenic corn to control European corn borer, Ostrinia nubilalis.  We gathered data from literature on the life cycle of European corn borer and corn crop maturation to study the role that phenological relationships may play in rresistance evolution.  In addition, we simulated hypothetical titer declines resulting in increased survival in European corn borer populations infesting transgenic corn using a model of population dynamics and genetics.  The relationship between European corn borer hatching period and corn maturation varies greatly from site to site and year to year.  The peak of the hatching period in the late summer generation of the European corn borer occurs at or after the average midpoint of the dough stage of corn.  The last larvae tend to hatch after the dough stage is past and after the midpoint of the dent stage.  In simulations where 5% of a region is planted with nontransgenic corn in separate refuge plots and 95% is planted with transgenic corn, complete loss of titer as a result of senescence produces resistance at the 3% resistance-allele level after 5-42 years, which is less than the 83 years predicted by the standard model for resistance development when the transgenic corn loses no titer as a result of senescence.  We hypothesize that genetically engineered corn toxins will often decrease in leaf and stem titer as crops reach maturation.  The insects feeding and surviving on a crop during its senescence may have important consequences for the population genetics of the breakdown of host plant resistance.